Tyler LeBaron's Research

Tyler LeBaron’s Continued Research

EDUCATION

Doctor of Philosophy in Animal Physiology
Masters in Exercise and Sports Conditioning
Bachelor of Science in Biochemistry

Internship at Nagoya University Japan to research the molecular mechanism of H_2. Relevant course work include: Biochemistry, Physiology, Advanced Exercise Physiology, Nutritional Biochemistry, Molecular Cell Biology, Quantitative Chemical Analysis, Biology Analysis Techniques

2022 Hasegawa T, Ito M, Hasegawa S, Teranishi M, Takeda K, Negishi S, Nishiwaki H, Takeda JI, LeBaron TW, Ohno K. Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response. International journal of molecular sciences. 2022 Mar 7;23(5):2888.
2021 Singh RB, Ghazi Halabi GF, Rai RH, Tarnava AT, LeBaron TW*. Molecular hydrogen as an adjuvant therapy may be associated with increased oxygen saturation and improved exercise tolerance in a COVID‐19 patient. Clinical Case Reports. 2021 Nov;9(11).
2021 Alwazeer D., Liu FF., WY Xiao., LeBaron TW*. Combating Oxidative Stress and Inflammation in COVID-19 by Molecular Hydrogen ‎Therapy: Mechanisms and Perspectives. Oxidative Medicine and Cellular Longevity 2021
2021 LeBaron TW., Shigeo Ohta. Reply to “Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study”¹ J. Physiology and Pharmacology. 99(10), pp.1114-1115.
2021 LeBaron TW*., Kharman J. Michael L. McCullough.An H₂-infused, nitric oxide-producing functional beverage as a neuroprotective agent for TBIs and concussions. J. Integrative Neuroscience 20, no. 3 (2021): 667-676.
2021 Hancock, J.T., LeBaron, TW., May, J., Thomas, A., Russell, G. Molecular Hydrogen: a new treatment for plants in the UK?New Trends in UK Plant Science Plants 10, no. 11 (2021): 2270.
2021 LeBaron TW., Asgharzadeh F., Khazei M., Kura B., Tarnava A., Slezak J., Molecular hydrogen is comparable to sulfasalazine as a treatment for DSS-induced ulcerative colitis in mice. EXCLI Journal, 20:1106-1117
2021 LeBaron TW*., Kharman J. Michael L. McCullough. Effects of an H₂-infused, nitric oxide-producing functional beverage on exercise and cognitive performance. Journal of Science and Medicine, 3(2)p79
2021 Hancock, J.T., LeBaron, T.W. and Russell, G., 2021. Molecular Hydrogen: Redox Reactions and Possible Biological Interactions. Reactive Oxygen Species, 11, pp.m17-m25.
2020 Barancik A., Kura B., LeBaron TW., Bolli R., Buday J., Slezak J. Molecular mechanisms and cellular systems associated with the medical effects of molecular hydrogen. Antioxidants, 9(12), p.1281.
2020 Slezak J, Kura B, LeBaron TW, Singal PK, Buday J, Barancik M. Oxidative stress and pathways of molecular hydrogen effects in medicine. Current Pharmaceutical Design. 2020. 26, 1-16
2020 T.W. LeBaron, M.L. McCullough, K.H. Ruppman Sr. 2020 A novel functional beverage for COVID-19 and other conditions: hypothesis and preliminary data, increased blood flow, and wound healing JTransl Sci, 6 (2020), pp. 1-6
2020 LeBaron, T.W., Singh, R.B., Fatima, G., Kartikey, K., Sharma, J.P., Ostojic, S.M., Gvozdjakova, A., Kura, B., Noda, M., Mojto, V. and Niaz, M.A., 2020. The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial.Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 13, p.889.
2020 Zhang X, Zhang Z, Su Z, Zhao Q, LeBaron TW, Li Q, Lyu B, Adzavon YM, Liu G, Liu M, Xie F. Hydrogen evolution and absorption phenomena in plasma membrane of higher plants. 2020 Jan 1.
2019 Korovljev, D., Stajer, V., Ostojic, J., LeBaron, T.W. and Ostojic, S.M., Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial.Clinics and Research in Hepatology and Gastroenterology, 43(6), pp.688-693.
2019 LeBaron, T.W., Kura, B., Kalocayova, B., Tribulova, N. and Slezak, J., 2019. A new approach for the prevention and treatment of cardiovascular disorders. Molecular hydrogen significantly reduces the effects of oxidative stress. Molecules, 24(11), p.2076.
2019 Mikami, T., Tano, K., Lee, H., Lee, H., Park, J., Ohta, F., LeBaron, T.W. and Ohta, S., 2019. Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study. Canadian journal of physiology and pharmacology, 97(9), pp.857-862
2019 LeBaron TW, Laher, I., Kura, B., & Slezak, J. Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes. Canadian journal of physiology and pharmacology, 2019; 97(9), pp.857-862
2019 Korovljev, D., Stajer, V., Ostojic, J., LeBaron, T.W. & Ostojic, S.M., 2019. Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial. Clinics and research in hepatology and gastroenterology. 2019 April (in press)
2019 LeBaron TW, Larson A, Ohta S, Mikami T, Barlow J, Bulloch J, Debeliso M. Acute Supplementation with Molecular Hydrogen Benefits Submaximal Exercise Indices. Randomized, Double-Blinded, Placebo-Controlled Crossover Pilot Study. J. Lifestyle Medicine 2019; 9:36-43
2019 Kura B, Kalocayova B, LeBaron TW, Frimmel K, Buday J, Surovy J, Slezak J. Regulation of microRNAs by molecular hydrogen contributes to the prevention of radiation-induced damage in the rat myocardium. Molecular and Cellular Biochemistry. 2019 Mar 4:1-2.
2018 Kura B, Bagchi AK, Singal PK, Barancik M, LeBaron TW, Valachova K, Soltes L, Slezak J. Molecular hydrogen (H₂): Potential in mitigating oxidative stress-induced cardiotoxicity. Canadian journal of physiology and pharmacology. 2018 Dec 13(ja).
2018 Jackson K, Dressler N, Ben-Shushan RS, Meerson A, LeBaron TW, Tamir S. Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model. World Journal of Gastroenterology. 2018 Dec 7;24(45):5095.
2018 Tyler W. LeBaron; Special Lecture: “Therapeutic and clinical effects of hydrogen gas” * Japanese-English translation, presented at medical-dental conference in Tokyo Japan (Dec. 15, 2018).
2018 Guo Q, Yin X, Qiao M, Jia Y, Chen D, Shao J, LeBaron TW, Gao Y, Jia B, Shi H. Hydrogen-rich water ameliorates autistic-like behavioral abnormalities in valproic acid-treated adolescent mice offspring. Frontiers in behavioral neuroscience. 2018;12:170.
2018 Tyler W. LeBaron; “Clinical effects of molecular hydrogen on neurodegenerative diseases” presented at Academy of Comprehensive Integrative Medicine. Orlando, Florida (Nov. 10th, 2015)
2018 Hirayama M, Ito M, Minato T, Yoritaka A, LeBaron TW, Ohno K. Inhalation of hydrogen gas elevates urinary 8-hydroxy-2′-deoxyguanine in Parkinson’s disease. Medical gas research. 2018 Oct;8(4):144.
2018 Tyler W. LeBaron; “Inhalation of hydrogen gas mildly elevates oxidative stress in Parkinson’s disease. Hormetic or toxic?” presented at first International conference on Hydrogen Medicine and Biology Beijing China Oct. 13, 2018.
2018 Tyler W. LeBaron; “Beneficial effects of hydrogen gas- involvement of miRNAs, Co-Q10 and ATP production presented at the International Hydrogen Industry Development Forum, organized by International Molecular Hydrogen Association (IMHA) in Guangzhou, China (Sept. 15, 2018)
2018 Shang L, Xie F, Li J, Zhang Y, Liu M, Zhao P, Ma X, LeBaron TW. Therapeutic potential of molecular hydrogen in ovarian cancer. Translational Cancer Research. 2018 Aug 14;7(4):988-95.
2018 Tyler W. LeBaron; “Practical Applications and Clinical Uses for Molecular Hydrogen” presented at SOPMED Medical Conference in Colorado Springs, Colorado (June 22^nd, 2018)
2018 Tyler W. LeBaron “Hydrogen: a therapeutic molecule for cardio and cerebrovascular diseases” presented at the 5^th European Section meeting of the International Academy of Cardiovascular Sciences (IACS-ES) in Bratislava, Slovakia (May 24, 2018).
2018 Liang; Y. Du; W. Li; X. Yin; N. Yang; A. Qie; T. W. LeBaron; J. Zhang; H. Chen; H. Shi. “SuHeXiang essential oil inhalation produces antidepressant- and anxiolytic-like effects in adult mice” Biological and Pharmaceutical Bulletin. 2018 May 9:b18-00082
2018 Tyler W. LeBaron & Mark Rosenberg “Clinical Applications for Molecular Hydrogen” presented at the Academy of Anti-Aging Medicine (A4M) in Hollywood, Florida (April13, 2018).
2018 Tyler W. LeBaron; “Hydrogen: a biologically-regenerative molecule with clinical applications” presented at the Academy of Regenerative Practices in Boca Raton, Florida (March 3, 2018).
2017 Tyler W. LeBaron; “Is Hydrogen an Antioxidant? Definitions and Explanations” presented at the 4^th Symposium of CPAM Chinese Hydrogen Biomedical Association (SCHBA) in Foshan, China (Dec. 6, 2017).
2017 Tyler W. LeBaron; “Hydrogen: an emerging medical gas with clinical significance” presented at 22^nd International Conference of FFC-10^th International Symposium of ASFFBC at Harvard Medical School, Boston MA, USA. (Sept. 23, 2017).
2017 Tyler W. LeBaron; “Molecular Hydrogen: from basic and clinical research to sports performance; an overview of the data from recent human studies” presented at the International Hydrogen Industry Development Forum, organized by International Molecular Hydrogen Association (IMHA) in Guangzhou, China (Sept. 14, 2017)
2017 Gao, Q., Song, H., Wang, X.T., Liang, Y., Xi, Y.J., Gao, Y., Guo, Q.J., LeBaron, T., Luo, Y.X., Li, S.C. and Yin, X. Molecular hydrogen increases resilience to stress in mice. Nature publication: Scientific Reports, 7 (2017)
2017 Tyler W. LeBaron; “Hydrogen: signal modulator for disease and inflammation” presented at SOPMED Medical Conference in Colorado Springs, Colorado (June 16^th, 2017)
2017 Tyler W. LeBaron; “Hydrogen: A Therapeutic Medical Gas” presented at conference and medical group in Jakarta Indonesia (March 8, 2017)
2016 Tyler W. LeBaron; “Hydrogen Revolution in Industry and Medical Biology” presented at the Korea International Symposium on Hydrogen in Seoul Korea (November 25, 2016)
2016 Tyler W. LeBaron; “Hydrogen: A Small Molecule with Great Clinical Significance” presented at ILADS Annual Scientific Medical Conference on Lyme Disease in Philadelphia, PA (November 5, 2016)
2016 Tyler W. LeBaron; “Hydrogen: an Ageless Molecule of an Aging Society; a Scientific Basis for the Amelioration of Inflammation, Oxidation, and Cellular Degeneration” presented at the 3^rd Symposium of Chinese Hydrogen Biomedical Association (SCHBA) in Taian city (September 25, 2016)
2016 Tyler W. LeBaron; “Hydrogen: an explosive molecule with explosive therapeutic effects” presented at the International Hydrogen Industry Development Forum, organized by International Molecular Hydrogen Association (IMHA) in Guangzhou, China (Sept. 9, 2016)
2016 Tyler W. LeBaron; “Hydrogen: A Therapeutic Molecule with Ergogenic Potential” presented at the 6^th Hydrogen Medicine Conference in Shenyang, China (July 24, 2016)
2016 Tyler W. LeBaron; “Hidrógeno molecular: La revolución de Salud y el Bienestar, presented at Global Conference in Querétaro Mexico (July 12^th, 2016)
2016 Tyler W. LeBaron; “Hydrogen Therapy: ‘Primum non nocere’ a revolution in health and wellness” presented at SOPMED Medical Conference in Salt Lake City, Utah (June 17^th, 2016)
2016 Tyler W. LeBaron; “Hydrogen: A Unique and Superior Antioxidant Molecule for Athletes” presented at the International Molecular Hydrogen Symposium in Shanghai (March 20, 2016)
2015 Tyler LeBaron; “Molecular Hydrogen: therapeutic and medical applications” presented at Age Management Medical Group. Las Vegas, Nevada (Dec. 8^th, 2015).
2015 Tyler LeBaron; “Molecular Hydrogen: therapeutic potential for neurodegenerative diseases” presented at Academy of Comprehensive Integrative Medicine. Orlando, Florida (Oct. 24^th, 2015)
2015 Tyler LeBaron; “Molecular Hydrogen: therapeutic and medical applications” presented at FIME Medical Expo. Miami, Florida. (Aug. 7^th, 2015).
2015 Tyler W. LeBaron; “Molecular Hydrogen: an evolutionary and molecular explanation for its ubiquitous biological effects on eukaryotes” presented at the 2^nd Molecular Hydrogen Biomedical Symposium. CPMA Chinese Hydrogen Biomedical Association (June 28, 2015)
2015 Tyler W. LeBaron; “Molecular Hydrogen in America: research, products, media, and awareness” presented at 5^thSymposium of Medical Molecular Hydrogen at Nagoya University (March 22, 2015) http://www.med.nagoya-u.ac.jp/neurogenetics/mmh2015/sub_program.html
2014 Meyers, Jonathan K., Tyler W. LeBaron, and David C. Collins. “The Journal of Kitchen Chemistry: A Tool for Instructing the Preparation of a Chemistry Journal Article.” Journal of Chemical Education. http://pubs.acs.org/doi/abs/10.1021/ed400671y
2013 Tyler W. LeBaron; “Changes in Oxidation-Reduction Potential of Aqueous Solutions as a Function of pH and Hydrogen Gas Concentration” The Journal of Kitchen Chemistry 2013. 1. P.12
2013 Tyler W. LeBaron; “Estimation of Hydrogen gas Concentration in Aqueous Solutions via Oxidation-Reduction Potential Measurements as a Function of pH” presented at BYU-I Research and Creative Works Conference, April 4, 2013. http://beta.byui.edu/Documents/instructional_development/rcw/2013%20Winter/RCW%20Winter%202013%20%282%29.pdf
2012 Tyler W. LeBaron; Determination of nitrate reduction in the presence of ascorbic acid at facilitative pH (Personal project—preliminary results and specific review presented in 2012).
2012 Tyler W. LeBaron; “Testosterone Booster Recommendation Report” (A critical review of purported supplements) http://scholar.google.com/scholar?q=%22Testosterone+Booster+Recommendation+Report%22&btnG=&hl=en&as_sdt=0%2C13
2011 Tyler W. LeBaron; “Creatine recommendation report” (Review of current work and elucidation of creatine stability with respect to various supplements http://scholar.google.com/scholar?q=%22creatine+recommendation+report%22+&btnG=&hl=en&as_sdt=0%2C13
2010 Tyler W. LeBaron; “Functional Water for the Prevention and Treatment of Disease (A comprehensive literature review)”, presented at BYU-I Research and Creative Works Conference, December 9, 2010. http://emp.byui.edu/PyperB/2010FallUGRC.htm
2010 Tyler W. LeBaron “Alkaline Reduced (electrolyzed) Water enhances time to exhaustion during lactate threshold running”, presented at BYU-I Research and Creative Works Conference, Mar 25, 2010 http://emp.byui.edu/PyperB/2010byuiugrc.htm