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  • Japanese 日本
  • Chinese 中文
  • Core Members
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  • Technical and Educational
    • Methods for Determining the Hydrogen Concentration
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Dr. Qin’s Expanded Researchadmin2019-02-12T23:53:54+00:00

Dr. Suchun Qin, M.D & PhD

Research publications (selected from more than 150 papers)

  1. Shu-Cun Qin, Koichi Kawano, Can Bruce, Min Lin, Charles Bisgaier, Alan R. Tall, and Xian-cheng Jiang, Phospholipid transfer protein gene knock-out mice have low density lipoprotein levels, due to hypercatabolism, and accumulate apoA-IV-rich lamellar lipoproteins. Journal of Lipid Research 2000; 41:269-276
  2. Koichi Kawano, Shu-Cun Qin, Min Lin, Alan R. Tall, and Xian-cheng Jiang. Cholesteryl Ester Transfer Protein and Phospholipid Transfer Protein Have Non-overlapping Functions in Vivo. Biol. Chem. 2000 275: 29477-29481.
  3. Xian-Cheng Jiang, Shu-Cun Qin, Chunping Qiao, Koichi Kawano, Min Lin, Anna Skold, Xiao Xiao & Alan R. Tall. Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid transfer protein deficiency. Nature Medicine 2001. 7(7):847-852
  4. Xian-Cheng Jiang, Alan R. Tall, Shu-Cun Qin, Min Lin, Martina Schneider, Florent Lalanne, Vale Deckert, Catherine Desrumaux, Anne Athias, Joseph L. Witztum. Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. Journal of Biological Chemistry 2002, 277(35): 31850-31856
  5. Koichi Kawano, Shu-Cun Qin, Claude Vieu, Xavier Collet, Xian-Cheng Jiang. Role of hepatic lipase and scavenger receptor BI in cleaning phospholipid/free cholesterol-rich lipoproteins in PLTP-deficient mice. Biochimica et Biophysica Acta 2002, 1583: 133-140
  6. J. Cenedella, JR Kuszak, KJ Al-Ghoul, Shucun Qin, and PS Sexton. Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb: Thom rats.  J. Lipid Res. 2003 44: 198-21
  7. Shucun Qin, Tianjiao Liu, Vaijinath S Kamanna, and Moti L Kashyap. Pioglitazone Stimulates Apolipoprotein A-I Production Without Affecting HDL Removal in HepG2 Cells- Involvement of PPAR. Arterioscler Thromb Vasc Biol  2007, 27:2428-2434 IF 7.221
  8. Shucun Qin, Tianjiao Liu, Vaijinath S Kamanna, and Moti L Kashyap. Rosuvastatin selectively stimulates apolipoprotein A-I but not apolipoprotein A-II synthesis in Hep G2 cells. Metabolism  2008, 57：973-979 IF 2.920
  9. Shobha H Ganji, Shucun Qin, Tianjiao Liu, Vaijinath S Kamanna, and Moti L Kashyap. Niacin inhibits LDL oxidation and redox-sensitive VCAM-1 and MCP-1 expression in human aortic endothelial cells. Atherosclerosis 2009, 202(1):68-75 IF 4.521
  10. Calvin Yeang, Shucun Qin, Kailian Chen, David Q. Wang, Xian-Cheng Jiang. Diet-induced lipid accumulation in phospholipids transfer protein-deficient mice: its atherogenicity and potential mechanism. Journal Lipid Research. 2010; 51:2993-3002 (SCI) IF 6.114
  11. Li Weihong, Wang Daxin, Song Guohua, Zuo Chunxia, Xianfu Qiao, Shucun Qin*: The effect of combination therapy of allicin and fenofibrate on high fat diet-induced vascular endothelium dysfunction and liver damage in rats. Lipids in Health and Disease. 2010. Nov 14;9(1):131. IF 2.239 [Epub ahead of print]
  12. Nana Yang, Dawei Li, Peng Jiao, Bin Chen, Shutong Yao, Hui Sang, Mingfeng Yang, Jiju Han, Ying Zhang, Shucun Qin*. The characteristics of endothelial progenitor cells derived from mononuclear cells of rat bone marrow in different culture conditions. Cytotechnology. 2010; 63(3):217-26. IF 1.276
  13. Guohua Song, Jia Liu, Zhenmei Zhao, Yang Yu, Hua Tian, Shutong Yao, Guoli Li, Shucun Qin*. Simvastatin reduces atherogenesis and promotes the expression of hepatic genes associated with reverse cholesterol transport in apoE-knockout mice fed high-fat diet. Lipids in Health and Disease. 10:8. IF 2.239
  14. Guohua Song, Hua Tian, Jia Liu, Hongle Zhang, Xuejun Sun, Shucun Qin*. H2 inhibits TNF-α-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor κB activation in endothelial cells. Biotechnology Letters 2011;33:1715-1722 IF768
  15. Wang Y, Jing L, Zhao XM*, Han JJ, Xia ZL, Qin SC, Wu YP, Sun XJ.Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model. Respir Res. 2011,12(1):26. (SCI) IF 3.127
  16. Yang Yu, Yanhong Si, Guohua Song, Tian Luo, Jiafu Wang, Shucun Qin* Ethanolic extract of propolis promotes reverse cholesterol transport and the expression of ATP-binding cassette transporter A1 and G1 in mice. Lipids, 2011;46(9):805-11. IF 2.381
  17. Daxin Wang, Jiju Han, Yang Yu, Xueping Li, Yun Wang, Hua Tian, Shoudong Guo, Shiguang Jin,Tian Luo, Shucun Qin*. Effect of chitosan oligosaccharide on plasma lipoprotein lipids and protein components, lecithin cholesterol acyl transferase and phospholipid transfer protein activities. Experimental Biology and Medicine. 2011;236(9):1064-9.. (SCI) IF 2.953.
  18. Zong CL, Yu Y, Song GH, Luo T, Li LQ, Wang XN, Qin SC* Chitosan oligosaccharides promote reverse cholesterol transport and expression of s cavenger receptor BI and CYP7A1 in mice. Exp Biol Med (Maywood). 2012 Feb 1;237(2):194-200
  19. Guohua Song, Hua Tian, Shucun Qin*, Xuejun Sun, Shutong Yao, Chuanlong Zong, Yingying Luo, Jia Liu, Yang Yu, Hui Sang, Xinnong Wang. Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice. Atherosclerosis 2012 Mar;221(1):55-65.
  20. Chuanlong Zong, Guohua Song§(equal contribution), Shutong Yao, Luqin Li, Yang Yu, Lei Feng, Shoudong Guo, Tian Luo, Shucun Qin*. Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet fed hamsters. Metabolism. 2012 61(6):794-800.
  21. Lihua Wei, Li Ge, Shucun Qin*, Yunzhi Shi, Changqing Du, Hui Du, Liwei Liu,Yang Yu, Xuejun Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig. Experimental Eye Research. 2012;94(1):117-27.
  22. Qin S, Kamanna VS, Lai JH, Liu T, Ganji SH, Zhang L, Bachovchin WW, Kashyap ML. Reverse D4F, an Apolipoprotein-AI Mimetic Peptide, Inhibits Atherosclerosis in ApoE-null Mice. J Cardiovasc Pharmacol Ther. 2012 17(3):334-43
  23. Gao LL, Feng L, Yao ST, Jiao P, Qin SC, Zhang W, Zhang YB, Li FR. Molecular Mechanisms of Celery Seed Extract Induced Apoptosis via S Phase Cell Cycle Arrest in the BGC-823 Human Stomach Cancer Cell Line. Asian Pac J Cancer Prev. 2011;12(10):2601-6
  24. Li FR, Jiao P, Yao ST, Sang H, Qin SC, Zhang W, Zhang YB, Gao LL. Paris polyphylla Smith extract induces apoptosis and activates cancer suppressor gene connexin26 expression. Asian Pac J Cancer Prev. 2012;13(1):205-9.
  25. Shutong Yao, Nana Yang, Guohua Song, Hui Sang, Hua Tian, Cheng Miao, Ying Zhang, Shucun Qin*. Minimally modified low-density lipoprotein induces macrophage endoplasmic reticulum stress via toll-like receptor 4. Biochim Biophys Acta. 2012; 1821(7):954-63.
  26. Yao S, Sang H, Song G, Yang N, Liu Q, Zhang Y, Jiao P, Zong C, Qin S*. Quercetin protects macrophages from oxidized low-density lipoprotein-induced apoptosis by inhibiting the endoplasmic reticulum stress-C/EBP homologous protein pathway. Exp Biol Med (Maywood). 2012 Jul 24.
  27. Guohua Song, Jia Liu, Yanhong Si, Shutong Yao, Jie Liu, Ping Zhu*, Shucun Qin*. SR-BI associates with ABCG1 and inhibits ABCG1-mediated cholesterol efflux from cells to high-density lipoprotein 3. Lipids in Health and Disease 2012 Sep 17;11(1):118. [Epub ahead of print]
  28. Shutong Yao, Chuanlong Zong, Ying Zhang, Hui Sang, Shucun Qin*. Activating Transcription Factor 6 Mediates Oxidized LDL-Induced Cholesterol Accumulation and Apoptosis in Macrophages by Up-Regulating CHOP Expression. Journal of Atherosclerosis and Thrombosis. 2013 20(1): 94-107.
  29. Zhao Z, Song G, Tian H, Yu Y, Tian X, Liu J, Yao S, Luo T, Qin S *. Triacetyl-3-hydroxyphenyladenosine, a derivative of cordycepin attenuates atherosclerosis in apolipoprotein E-knockout mice Exp Biol Med (Maywood). 2012 Nov 1;237(11):1262-72.
  30. Nana Yang, Shucun Qin*, Mengzan Wang, Bin Chen, Na Yuan, Yongqi Fang, Shutong Yao, Peng Jiao, Yang Yu, Ying Zhang, Jiafu Wang. Pinocembrin, a major flavonoid in propolis, improves the biological functions of EPCs derived from rat bone marrow through the PI3K-eNOS-NO signaling pathway. Cytotechnology. 2013 Aug;65(4):541-51.
  31. Sang H, Yuan N, Yao S, Li F, Wang J, Fang Y, Qin S*. Inhibitory effect of the combination therapy of simvastatin and pinocembrin on atherosclerosis in ApoE-deficient mice. Lipids Health Dis. 2012 Dec 5;11:166. doi: 10.1186/1476-511X-11-166.
  32. Yang N, Yao S, Wang M, Jiao P, Zhang Y, Qin S*. Apolipoprotein A-I mimetic peptide reverse D-4F improves the biological functions of mouse bone marrow-derived late EPCs via PI3K/AKT/eNOS pathway. Mol Cell Biochem. 2013 May;377(1-2):229-36.
  33. Zhang Y, Si Y, Yao S, Yang N, Song G, Sang H, Zu D, Xu X, Wang J, Qin S*. Celastrus orbiculatus Thunb. Decreases Athero-Susceptibility in Lipoproteins and the Aorta of Guinea Pigs Fed High Fat Diet. Lipids. 2013 Jun;48(6):619-31
  34. Song G, Li M, Sang H, Zhang L, Li X, Yao S, Yu Y, Zong C, Xue Y, Qin S*. Hydrogen-rich water decreases serum low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in patients with potential metabolic syndrome. J Lipid Res. 2013 54(7):1884-93
  35. Wang H, Yu Y, Chen W, Cui Y, Luo T, Ma J, Jiang XC, Qin S*.PLTP Deficiency Impairs Learning and Memory Capabilities Partially due to Alteration of Amyloid-β Metabolism in Old Mice. J Alzheimers Dis. 2014;39(1):79-88. doi: 10.3233/JAD-130812
  36. Fang Y, Sang H, Yuan N, Sun H, Yao S, Wang J, Qin S*. Ethanolic extract of propolis inhibits atherosclerosis in ApoE-knockout mice. Lipids Health Dis. 2013 Aug 13;12(1):123.
  37. Yu Y, Guo S, Feng Y, Feng L, Cui Y, Song G, Luo T, Zhang K, Wang Y, Jiang XC, Qin S*. Phospholipid Transfer Protein Deficiency Decreases the Content of S1P in HDL via the Loss of its Transfer Capability. Lipids. 2014 Feb;49(2):183-90. doi: 10.1007/s11745-013-3850-y. Epub 2013 Oct 25
  38. Zhang Y, Si Y, Zhai L, Yang N, Yao S, Sang H, Zu D, Xu X, Qin S, Wang J. Celastrus orbiculatus Thunb. ameliorates high-fat diet-induced non-alcoholic fatty liver disease in guinea pigs. Pharmazie 2013 Oct;68(10):850-4
  39. Yao S, Miao C, Tian H, Sang H, Yang Nana, Jiao P, Han J, Zong C, Qin S.Endoplasmic Reticulum Stress Promotes Macrophage-derived Foam Cell Formation by Upregulating CD36 Expression. J Biol Chem. 2014 Feb 14;289(7):4032-42.SCI IF= 4.65
  40. Shoudong Guo, Yang Yu, Nan Zhang, Yingjie Cui, Lei Zhai, Helou Li, Ying Zhang, Fuyu Li, Yujie Kan, Shucun Qin* Higher level of plasma bioactive molecule sphingosine 1-phosphate in women is associated with estrogen. BBA-LIP 2014 Mar 3;1841(6):836-846.
  41. Zhou T, He Q, Tong Y, Zhan R, Xu F, Fan D, Guo X, Han H, Qin S*, Chui D. Phospholipid transfer protein (PLTP) deficiency impaired blood-brain barrier integrity by increasing cerebrovascular oxidative stress. Biochem Biophys Res Commun. 2014 Mar 7;445(2):352-6.
  42. Shucun Qin , Guohua Song, Yang Yu. Phospholipid transfer protein in diabetes, metabolic syndrome and obesity. Cardiovascular and Hematological Disorders-Drug Target 2014;14(2):149-53.
  43. Liu J, Yao S, Wang S, Jiao P, Song G, Yu Y, Zhu P, Qin S*. D-4F, an apolipoprotein A-I mimetic peptide, protects HUVECs from ox-LDL-induced injury by preventing the downregulation of pigment epithelium-derived factor expression. J Cardiovasc Pharmacol. 2014 Jun;63(6):553-61. 2014 Apr 4. [Epub ahead of print]
  44. Si Y, Zhang Y, Zhao J, Guo S, Zhai L, Yao S, Sang H, Yang N, Song G, Gu J, Qin S.Niacin inhibits vascular inflammation via downregulating nuclear transcription factor-κB signaling pathway. Mediators Inflamm. 2014;2014:263786. doi: 10.1155/2014/263786. Epub 2014 May 27.
  45. He L, Qin S, Dang L, Song G, Yao S, Yang N, Li Y. Psoriasis decreases the anti-oxidation and anti-inflammation properties of high-density lipoprotein. Biochim Biophys Acta. 2014 Dec;1841(12):1709-15.
  46. Ke Zhang, Xiaoling Liu, Yang Yu, Tian Luo, Lin Wang, Chen Ge, Xinxin Liu, Jiantao Song, Xiancheng Jiang, Yun Zhang, Shucun Qin, Mei Zhang. Phospholipid Transfer Protein Destabilizes Mouse Atherosclerotic Plaque. Arterioscler Thromb Vasc Biol  2014;34(12):2537-44.
  47. Hui Sang, Shutong Yao, Liying Zhang, Xiuhong Li, Nana Yang, Jianxiang Zhao, Li Zhao, Yanhong Si, Ying Zhang, Xiaohong Lv, Yazhuo Xue, Shucun Qin*. Walk-Run Training Improves the anti-inflammation Properties of High-Density Lipoprotein in the Patients with Metabolic Syndrome. Journal of Clinical Endocrinology & Metabolism 2015 Mar;100(3):870-9.
  48. Jiang H, Yazdanyar A, Lou B, Chen Y, Zhao X, Li R, Hoang Bui H, Kuo MS, Navab M, Qin S, Li Z, Jin W, Jiang XC. Adipocyte phospholipid transfer protein and lipoprotein metabolism. Arterioscler Thromb Vasc Biol. 2015;35(2):316-22
  49. Yao S, Tian H, Miao C, Zhang DW, Zhao L, Li Y, Yang N, Jiao P, Sang H, Guo S, Wang Y, Qin S. D4F alleviates macrophage-derived foam cell apoptosis by inhibiting endoplasmic reticulum stress-CHOP pathway. J Lipid Res. 2015, 56(4):836-47
  50. Yu Y, Luo T, Liu S, Song G, Han J, Wang Y, Yao S, Feng L, Qin S. Chitosan Oligosaccharides Attenuate Atherosclerosis and Decrease Non-HDL in ApoE-/- Mice. J Atheroscler Thromb. 2015, 22(9):926-41.
  51. Jing L, Wang Y, Zhao XM, Zhao B, Han JJ, Qin SC, Sun XJ. Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats. Heart Lung Circ. 2015, 24(6):602-10.
  52. Liu M, Chen Y, Zhang L, Wang Q, Ma X, Li X, Xiang R, Zhu Y, Qin S, Yu Y, Jiang XC, Duan Y, Han J.Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II. J Biol Chem. 2015 Jun 5;290(23):14418-29.
  53. Song G, Lin Q, Zhao H, Liu M, Ye F, Sun Y, Yu Y, Guo S, Jiao P, Wu Y, Ding G, Xiao Q, Qin S*. Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial. J Clin Endocrinol Metab. 2015 Jul;100(7):2724-33.
  54. Song G, Zong C, Zhang Z, Yu Y, Yao S, Jiao P, Tian H, Zhai L, Zhao H, Tian S, Zhang X, Wu Y, Sun X, Qin S*. Molecular Hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor knockout mice. Free Radic Biol Med. 2015, 87:58-68.
  55. Tong Y, Sun Y, Tian X, Zhou T, Wang H, Zhang T, Zhan R, Zhao L, Kuerban B, Li Z, Wang Q, Jin Y, Fan D, Guo X, Han H, Qin S*, Chui D. Phospholipid Transfer Protein (PLTP) Deficiency Accelerates Memory Dysfunction through Altering Amyloid Precursor Protein (APP) Processing in a Mouse Model of Alzheimer’s Disease. Hum Mol Genet. 2015, 24(19):5388-403.
  56. Nana Y, Peng J, Jianlin Z, Xiangjian Z, Shutong Y, Enxin Z, Bin L, Chuanlong Z, Hua T, Yanhong S, Yunsai D, Shucun Q, Hui W.  Reverse-D-4F Increases the Number of Endothelial Progenitor Cells and Improves Endothelial Progenitor Cell Dysfunctions in High Fat Diet Mice. PLoS One. 2015 Sep 23;10(9):e0138832. doi: 10.1371/journal.pone.0138832. eCollection 2015
  57. Zong C, Song G, Yao S, Guo S, Yu Y, Yang N, Guo Z, Qin S. Cigarette smoke exposure impairs reverse cholesterol transport which can be minimized by treatment of hydrogen-saturated saline. Lipids Health Dis. 2015 Dec 3;14:159. doi: 10.1186/s12944-015-0160-9
  58. Yu Y, Cui Y, Zhao Y, Liu S, Song G, Jiao P, Li B, Luo T, Guo S, Zhang X, Wang H, Jiang XC, Qin S. The binding capability of plasma phospholipid transfer protein, but not HDL pool size, is critical to repress LPS induced inflammation. Sci Rep. 2016 Feb 9;6:20845. doi: 10.1038/srep20845
  59. Gu HM, Wang F, Alabi A, Deng S, Qin S, Zhang DW. Identification of an Amino Acid Residue Critical for Plasma Membrane Localization of ATP-Binding Cassette Transporter G1-Brief Report. Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):253-5.
  60. Tian H, Liu Q, Qin S, Zong C, Zhang Y, Yao S, Yang N, Guan T, Guo S. Synthesis and cardiovascular protective effects of quercetin 7-O-sialic acid. J Cell Mol Med. 2016 Aug 11. doi: 10.1111/jcmm.12943. [Epub ahead of print] IF 4.014
  61. Wang Y, Qin S, Pen G, Chen D, Han C, Miao C, Lu B, Su C, Feng S, Li W, Han J, Cho NC, Si Y.  Potential ocular protection and dynamic observation of Polygonatum sibiricum polysaccharide against streptozocin-induced diabetic rats’ model. Exp Biol Med (Maywood). 2016 Aug 9. pii: 1535370216663866. [Epub ahead of print]
  62. Song G, Wu X, Zhang P, Yu Y, Yang M, Jiao P, Wang N, Song H, Wu Y, Zhang X, Liu H, Qin S. High-density lipoprotein inhibits ox-LDL-induced adipokine secretion by upregulating SR-BI expression and suppressing ER Stress pathway. Sci Rep. 2016 Jul 29;6:30889. doi: 10.1038/srep30889
  63. Dong R, Li F, Qin S, Wang Y, Si Y, Xu X, Tian H, Zhai L, Zhang G, Li Y, Zhou Y, Zhang Y, Zhang N, Guo S. Dataset on inflammatory proteins expressions and sialic acid levels in apolipoprotein E-deficient mice with administration of N-acetylneuraminic acid and/or quercetin. Data Brief. 2016 Jun 22;8:613-7. doi: 10.1016/j.dib.2016.06.020.
  64. Guo S, Tian H, Dong R, Yang N, Zhang Y, Yao S, Li Y, Zhou Y, Si Y, Qin S. Exogenous supplement of N-acetylneuraminic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis. 2016 Aug;251:183-91.
  65. Bai X, Liu S, Yuan L, Xie Y, Li T, Wang L, Wang X, Zhang T, Qin S, Song G, Ge L, Wang Z. Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice. Brain Res. 2016 Sep 1;1646:410-7.
  66. Si Y, Zhang Y, Chen X, Zhai L, Zhou G, Yu A, Cao H, Shucun Q. Phospholipid transfer protein deficiency in mice impairs macrophage reverse cholesterol transport in vivo. Exp Biol Med (Maywood). 2016 Jul;241(13):1466-72.
  67. Zhang Y, Si Y, Zhai L, Guo S, Zhao J, Sang H, Pang X, Zhang X, Chen A, Qin S. Celastrus Orbiculatus Thunb. Reduces Lipid Accumulation by Promoting Reverse Cholesterol Transport in Hyperlipidemic Mice. Lipids. 2016 Jun;51(6):677-92.

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